| Function | Pore-forming subunit of the olfactory cyclic nucleotide-gated channel. Operates in the cilia of olfactory sensory neurons where chemical stimulation of the odorant is converted to an electrical signal. Mediates odorant-induced cAMP-dependent Ca(2+) influx triggering neuron depolarization. The rise of intracellular Ca(2+) levels potentiates the olfactory response by activating Ca(2+)-dependent Cl(-) channels, but it also serves as a negative feedback signal to desensitize the channel for rapid adaptation to odorants. Conducts cAMP- and cGMP-gated ion currents, with permeability for monovalent and divalent cations. |
| Protein Name | Cyclic Nucleotide-Gated Channel Alpha-4Cng Channel Alpha-4Cnga4Olfactory Cyclic Nucleotide-Gated Channel Subunit 2Ocnc2 |
| Database Links | Reactome: R-HSA-381753Reactome: R-HSA-5620916 |
| Cellular Localisation | Cell ProjectionCilium MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Cyclic Nucleotide-Gated Channel Alpha-4 antibodyAnti-Cng Channel Alpha-4 antibodyAnti-Cnga4 antibodyAnti-Olfactory Cyclic Nucleotide-Gated Channel Subunit 2 antibodyAnti-Ocnc2 antibodyAnti-CNGA4 antibody |
Information sourced from Uniprot.org
