Anti-CNGA4 antibody (416-575) (STJ116919)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CNGA4 (416-575) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CNGA4 |
| Gene ID | 1262 |
| Uniprot ID | CNGA4_HUMAN |
| Immunogen Region | 416-575 |
| Immunogen Sequence | ISIINIKGNMSGNRRTANIK SLGYSDLFCLSKEDLREVLS EYPQAQTIMEEKGREILLKM NKLDVNAEAAEIALQEATES RLRGLDQQLDDLQTKFARLL AELESSALKIAYRIERLEWQ TREWPMPEDLAEADDEGEPE EGTSKDEEGRASQEGPPGPE |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 416-575 of human CNGA4 (NP_001032406.1). |
Additional Info
| Function | Pore-forming subunit of the olfactory cyclic nucleotide-gated channel. Operates in the cilia of olfactory sensory neurons where chemical stimulation of the odorant is converted to an electrical signal. Mediates odorant-induced cAMP-dependent Ca(2+) influx triggering neuron depolarization. The rise of intracellular Ca(2+) levels potentiates the olfactory response by activating Ca(2+)-dependent Cl(-) channels, but it also serves as a negative feedback signal to desensitize the channel for rapid adaptation to odorants. Conducts cAMP- and cGMP-gated ion currents, with permeability for monovalent and divalent cations. |
| Protein Name | Cyclic Nucleotide-Gated Channel Alpha-4Cng Channel Alpha-4Cnga4Olfactory Cyclic Nucleotide-Gated Channel Subunit 2Ocnc2 |
| Database Links | Reactome: R-HSA-381753Reactome: R-HSA-5620916 |
| Cellular Localisation | Cell ProjectionCilium MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Cyclic Nucleotide-Gated Channel Alpha-4 antibodyAnti-Cng Channel Alpha-4 antibodyAnti-Cnga4 antibodyAnti-Olfactory Cyclic Nucleotide-Gated Channel Subunit 2 antibodyAnti-Ocnc2 antibodyAnti-CNGA4 antibody |
Information sourced from Uniprot.org