Anti-CMYA5 antibody (3866-3916 aa) (STJ196582)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human CMYA5 at the amino acid range 3866-3916
General Information
| Short Description | Rabbit polyclonal anti-Cardiomyopathy-associated protein 5 (3866-3916 aa) for use in IHC and IF in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC-P 1:50-200IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CMYA5 |
| Gene ID | 202333 |
| Uniprot ID | CMYA5_HUMAN |
| Immunogen | Synthesized peptide derived from the human CMYA5 at the amino acid range 3866-3916 |
| Immunogen Region | 3866-3916 aa |
| Specificity | This antibody detects endogenous levels of CMYA5 at Human/Mouse |
Additional Info
| Post Translational Modifications | Phosphorylated by PKA. |
| Function | May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A. May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration. Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle. |
| Protein Name | Cardiomyopathy-Associated Protein 5Dystrobrevin-Binding Protein 2Genethonin-3MyosprynSpry Domain-Containing Protein 2Tripartite Motif-Containing Protein 76 |
| Database Links | |
| Cellular Localisation | NucleusSarcoplasmic ReticulumCytoplasmPerinuclear RegionMyofibrilSarcomereM LineFound Predominantly At The Periphery Of The Nucleus But Also Throughout The CellLocalized In LysosomesIn Skeletal MusclesLocalizes Along Myofiber PeripheryAt CostameresPredominantly Flanks Z-DisksOccasionally Present At The M-Band LevelColocalized With Ryr2 In The Sarcoplasmic Reticulum |
| Alternative Antibody Names | Anti-Cardiomyopathy-Associated Protein 5 antibodyAnti-Dystrobrevin-Binding Protein 2 antibodyAnti-Genethonin-3 antibodyAnti-Myospryn antibodyAnti-Spry Domain-Containing Protein 2 antibodyAnti-Tripartite Motif-Containing Protein 76 antibodyAnti-CMYA5 antibodyAnti-C5orf10 antibodyAnti-DTNBP2 antibodyAnti-SPRYD2 antibodyAnti-TRIM76 antibody |
Information sourced from Uniprot.org