| Host: |
Rabbit |
| Applications: |
WB/IHC/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CLIC4 (1-253) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500IHC-P 1:50-1:200IF/ICC 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CLIC4 |
| Gene ID: |
25932 |
| Uniprot ID: |
CLIC4_HUMAN |
| Immunogen Region: |
1-253 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-253 of human CLIC4 (NP_039234.1). |
| Immunogen Sequence: |
MALSMPLNGLKEEDKEPLIE LFVKAGSDGESIGNCPFSQR LFMILWLKGVVFSVTTVDLK RKPADLQNLAPGTHPPFITF NSEVKTDVNKIEEFLEEVLC PPKYLKLSPKHPESNTAGMD IFAKFSAYIKNSRPEANEAL ERGLLKTLQKLDEYLNSPLP DEIDENSMEDIKFSTRKFLD GNEMTLADCNLLPKLHIVKV VAKKYRNFDIPKEMTGIWRY LTNAYSRDEFTNTCPSDKE |
| Tissue Specificity | Detected in epithelial cells from colon, esophagus and kidney (at protein level). Expression is prominent in heart, kidney, placenta and skeletal muscle. |
| Function | Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). |
| Protein Name | Chloride Intracellular Channel Protein 4Intracellular Chloride Ion Channel Protein P64h1 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCytoplasmic Vesicle MembraneSingle-Pass Membrane ProteinNucleusCell MembraneMitochondrionCell JunctionColocalized With Akap9 At The Centrosome And MidbodyExists Both As Soluble Cytoplasmic Protein And As Membrane Protein With Probably A Single Transmembrane DomainPresent In An Intracellular Vesicular Compartment That Likely Represent Trans-Golgi Network VesiclesMight Not Be Present In The Nucleus Of Cardiac Cells |
| Alternative Antibody Names | Anti-Chloride Intracellular Channel Protein 4 antibodyAnti-Intracellular Chloride Ion Channel Protein P64h1 antibodyAnti-CLIC4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
