Anti-CLEC2D antibody (60-154) (STJ112453)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CLEC2D (60-154) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CLEC2D |
| Gene ID | 29121 |
| Uniprot ID | CLC2D_HUMAN |
| Immunogen Region | 60-154 |
| Immunogen Sequence | RANCHQEPSVCLQAACPESW IGFQRKCFYFSDDTKNWTSS QRFCDSQDADLAQVESFQEL NFLLRYKGPSDHWIGLSREQ GQPWKWINGTEWTRQ |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 60-154 of human CLEC2D (NP_037401.1). |
Additional Info
| Tissue Specificity | Detected in peripheral blood leukocytes, osteoblasts, lymph node, thymus and spleen. Isoform 1, isoform 2 and isoform 4 are expressed in T- and B-lymphocytes, and at lower levels in NK cells. They are also expressed in B-cell lines and LPS-matured monocyte-derived dendritic cells. |
| Post Translational Modifications | N-glycosylated. |
| Function | Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Inhibits bone resorption. Modulates the release of interferon-gamma. Binds high molecular weight sulfated glycosaminoglycans. |
| Protein Name | C-Type Lectin Domain Family 2 Member DLectin-Like Nk Cell ReceptorLectin-Like Transcript 1Llt-1Osteoclast Inhibitory Lectin |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinIsoform 2: Endoplasmic ReticulumIsoform 4: Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-C-Type Lectin Domain Family 2 Member D antibodyAnti-Lectin-Like Nk Cell Receptor antibodyAnti-Lectin-Like Transcript 1 antibodyAnti-Llt-1 antibodyAnti-Osteoclast Inhibitory Lectin antibodyAnti-CLEC2D antibodyAnti-CLAX antibodyAnti-LLT1 antibodyAnti-OCIL antibody |
Information sourced from Uniprot.org