Anti-CLEC2B antibody (40-120) (STJ119464)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CLEC2B (40-120) antibody for use in WB and ELISA in rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CLEC2B |
| Gene ID | 9976 |
| Uniprot ID | CLC2B_HUMAN |
| Immunogen Region | 40-120 |
| Immunogen Sequence | IGFQNKCYYFSKEEGDWNSS KYNCSTQHADLTIIDNIEEM NFLRRYKCSSDHWIGLKMAK NRTGQWVDGATFTKSFGMRG S |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 40-120 of human CLEC2B (NP_005118.2). |
Additional Info
| Tissue Specificity | Expressed preferentially in lymphoid tissues, and in most hematopoietic cell types. |
| Post Translational Modifications | (Microbial infection) Ubiquitinated by human herpesvirus 8 protein K5, leading to endolysosomal degradation. N-linked glycosylated.required to enable surface expression and the extent of surface expression correlates with the number of functional conventional N-glycosylation sites. |
| Function | Membrane-bound protein expressed on myeloid cells which acts as a ligand to stimulate the activating receptor NKp80/KLRF1, expressed on the surface of natural killer (NK) cells. In turn, stimulates NK-cell cytotoxicity and cytokine production leading to the cytolysis of malignant CLEC2B-expressing myeloid cells. |
| Protein Name | C-Type Lectin Domain Family 2 Member BActivation-Induced C-Type LectinC-Type Lectin Superfamily Member 2Ifn-Alpha-2b-Inducing-Related Protein 1 |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinGolgi Apparatus MembraneResting Nk Cells Contain Intracellular Stores Of Clec2b Associated With The Golgi Complex |
| Alternative Antibody Names | Anti-C-Type Lectin Domain Family 2 Member B antibodyAnti-Activation-Induced C-Type Lectin antibodyAnti-C-Type Lectin Superfamily Member 2 antibodyAnti-Ifn-Alpha-2b-Inducing-Related Protein 1 antibodyAnti-CLEC2B antibodyAnti-AICL antibodyAnti-CLECSF2 antibodyAnti-IFNRG1 antibody |
Information sourced from Uniprot.org