| Tissue Specificity | Expressed preferentially in lymphoid tissues, and in most hematopoietic cell types. |
| Post Translational Modifications | (Microbial infection) Ubiquitinated by human herpesvirus 8 protein K5, leading to endolysosomal degradation. N-linked glycosylated.required to enable surface expression and the extent of surface expression correlates with the number of functional conventional N-glycosylation sites. |
| Function | Membrane-bound protein expressed on myeloid cells which acts as a ligand to stimulate the activating receptor NKp80/KLRF1, expressed on the surface of natural killer (NK) cells. In turn, stimulates NK-cell cytotoxicity and cytokine production leading to the cytolysis of malignant CLEC2B-expressing myeloid cells. |
| Protein Name | C-Type Lectin Domain Family 2 Member BActivation-Induced C-Type LectinC-Type Lectin Superfamily Member 2Ifn-Alpha-2b-Inducing-Related Protein 1 |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinGolgi Apparatus MembraneResting Nk Cells Contain Intracellular Stores Of Clec2b Associated With The Golgi Complex |
| Alternative Antibody Names | Anti-C-Type Lectin Domain Family 2 Member B antibodyAnti-Activation-Induced C-Type Lectin antibodyAnti-C-Type Lectin Superfamily Member 2 antibodyAnti-Ifn-Alpha-2b-Inducing-Related Protein 1 antibodyAnti-CLEC2B antibodyAnti-AICL antibodyAnti-CLECSF2 antibodyAnti-IFNRG1 antibody |
Information sourced from Uniprot.org
