Anti-CLEC2/CLEC1B antibody (Internal) (STJ71575)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-CLEC2/CLEC1B (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:1000.WB: Approx 28kDa band observed in human bone marrow and human kidney lysates (calculated MW of 26.6kDa according to NP_001092901.1). Recommended concentration: 1-3µg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | CLEC1B |
| Gene ID | 51266 |
| Uniprot ID | CLC1B_HUMAN |
| Accession Number | NP_001092901.1; NP_057593.3 |
| Immunogen Region | Internal |
| Immunogen Sequence | KGHKCSPCDTNWRY |
| Specificity | This antibody is expected to recognize both reported isoforms (NP_001092901.1; NP_057593.3) |
Additional Info
| Post Translational Modifications | Glycosylated. Phosphorylated on tyrosine residue in response to rhodocytin binding. |
| Function | C-type lectin-like receptor that functions as a platelet receptor for the lymphatic endothelial marker, PDPN. After ligand activation, signals via sequential activation of SRC and SYK tyrosine kinases leading to activation of PLCG2. (Microbial infection) Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (SYK) and initiation of downstream tyrosine phosphorylation events and activation of PLCG2. (Microbial infection) Acts as an attachment factor for Human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets. |
| Protein Name | C-Type Lectin Domain Family 1 Member BC-Type Lectin-Like Receptor 2Clec-2 |
| Database Links | Reactome: R-HSA-114604Reactome: R-HSA-9707616 |
| Cellular Localisation | MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-C-Type Lectin Domain Family 1 Member B antibodyAnti-C-Type Lectin-Like Receptor 2 antibodyAnti-Clec-2 antibodyAnti-CLEC1B antibodyAnti-CLEC2 antibodyAnti-UNQ721 antibodyAnti-PRO1384 antibody |
Information sourced from Uniprot.org