Anti-CLEC1B antibody (22-196) (STJ112012)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CLEC1B (22-196) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CLEC1B |
| Gene ID | 51266 |
| Uniprot ID | CLC1B_HUMAN |
| Immunogen Region | 22-196 |
| Immunogen Sequence | AVMQRNYLQGENENRTGTLQ QLAKRFCQYVVKQSELKGTF KGHKCSPCDTNWRYYGDSCY GFFRHNLTWEESKQYCTDMN ATLLKIDNRNIVEYIKARTH LIRWVGLSRQKSNEVWKWED GSVISENMFEFLEDGKGNMN CAYFHNGKMHPTFCENKHYL MCERKAGMTKVDQLP |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 22-196 of human CLEC1B (NP_001092901.1). |
Additional Info
| Tissue Specificity | Expressed preferentially in the liver. Also expressed in immune cells of myeloid origin and on the surface of platelets. |
| Post Translational Modifications | Glycosylated. Phosphorylated on tyrosine residue in response to rhodocytin binding. |
| Function | C-type lectin-like receptor that functions as a platelet receptor for the lymphatic endothelial marker, PDPN. After ligand activation, signals via sequential activation of SRC and SYK tyrosine kinases leading to activation of PLCG2. (Microbial infection) Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (SYK) and initiation of downstream tyrosine phosphorylation events and activation of PLCG2. (Microbial infection) Acts as an attachment factor for Human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets. |
| Protein Name | C-Type Lectin Domain Family 1 Member BC-Type Lectin-Like Receptor 2Clec-2 |
| Database Links | Reactome: R-HSA-114604Reactome: R-HSA-9707616 |
| Cellular Localisation | MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-C-Type Lectin Domain Family 1 Member B antibodyAnti-C-Type Lectin-Like Receptor 2 antibodyAnti-Clec-2 antibodyAnti-CLEC1B antibodyAnti-CLEC2 antibodyAnti-UNQ721 antibodyAnti-PRO1384 antibody |
Information sourced from Uniprot.org