Anti-Cleaved-PRSS8-Ile45, Heavy Chain antibody (44-45) (STJA0005908)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human PRSS8 (heavy chain, Cleaved-Ile45)
General Information
| Short Description | Rabbit polyclonal anti-Cleaved-Prostasin-Ile45, Heavy Chain (44-45) for use in WB and IHC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-p 1:50-300 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PRSS8 |
| Gene ID | 5652 |
| Uniprot ID | PRSS8_HUMAN |
| Immunogen | Synthesized peptide derived from human PRSS8 (heavy chain, Cleaved-Ile45) |
| Immunogen Region | 44-45 |
| Specificity | This antibody detects endogenous levels of Human, Mouse, Rat PRSS8 (heavy chain, Cleaved-Ile45, protein was cleaved amino acid sequence between 44-45 ) |
Additional Info
| Tissue Specificity | Found in prostate, liver, salivary gland, kidney, lung, pancreas, colon, bronchus and renal proximal tubular cells. In the prostate gland it may be synthesized in epithelial cells, secreted into the ducts, and excreted into the seminal fluid. |
| Function | Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G). |
| Protein Name | ProstasinChannel-Activating Protease 1Cap1Serine Protease 8 Cleaved Into - Prostasin Light Chain - Prostasin Heavy Chain |
| Database Links | Reactome: R-HSA-6809371 |
| Cellular Localisation | Prostasin: Cell MembraneSingle-Pass Membrane ProteinProstasin Light Chain: SecretedExtracellular SpaceFound In The Seminal FluidSecreted After Cleavage Of Its C-TerminusProstasin Heavy Chain: Secreted |
| Alternative Antibody Names | Anti-Prostasin antibodyAnti-Channel-Activating Protease 1 antibodyAnti-Cap1 antibodyAnti-Serine Protease 8 Cleaved Into - Prostasin Light Chain - Prostasin Heavy Chain antibodyAnti-PRSS8 antibody |
Information sourced from Uniprot.org