• Immunohistochemical analysis of paraffin-embedded human Colon cancer. 1, Antibody was diluted at 1:200 (4°C overnight). 2, Tris-EDTA, pH9.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 45min).

Anti-Cleaved-PRSS8-Ile45, Heavy Chain antibody (44-45) (STJA0005908)

SKU:
STJA0005908

€57.50 - €282.50
Current Stock:
Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Cleaved-Prostasin-Ile45, Heavy Chain (44-45) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
IHC-p 1:50-300
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PRSS8
Gene ID: 5652
Uniprot ID: PRSS8_HUMAN
Immunogen Region: 44-45
Specificity: This antibody detects endogenous levels of Human, Mouse, Rat PRSS8 (heavy chain, Cleaved-Ile45, protein was cleaved amino acid sequence between 44-45 )
Immunogen: Synthesized peptide derived from human PRSS8 (heavy chain, Cleaved-Ile45)
Tissue Specificity Found in prostate, liver, salivary gland, kidney, lung, pancreas, colon, bronchus and renal proximal tubular cells. In the prostate gland it may be synthesized in epithelial cells, secreted into the ducts, and excreted into the seminal fluid.
Function Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G).
Protein Name Prostasin
Channel-Activating Protease 1
Cap1
Serine Protease 8 Cleaved Into - Prostasin Light Chain - Prostasin Heavy Chain
Database Links Reactome: R-HSA-6809371
Cellular Localisation Prostasin: Cell Membrane
Single-Pass Membrane Protein
Prostasin Light Chain: Secreted
Extracellular Space
Found In The Seminal Fluid
Secreted After Cleavage Of Its C-Terminus
Prostasin Heavy Chain: Secreted
Alternative Antibody Names Anti-Prostasin antibody
Anti-Channel-Activating Protease 1 antibody
Anti-Cap1 antibody
Anti-Serine Protease 8 Cleaved Into - Prostasin Light Chain - Prostasin Heavy Chain antibody
Anti-PRSS8 antibody

Information sourced from Uniprot.org

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