• Immunohistochemical analysis of paraffin-embedded human liver cancer. 1, Antibody was diluted at 1:200 (4°C overnight). 2, Tris-EDTA, pH9.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 45min).

Anti-Cleaved-KLK14-Ile25 antibody (24-25) (STJA0005882)

SKU:
STJA0005882

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Cleaved-Kallikrein-14-Ile25 (24-25) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
IHC-p 1:50-300
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: KLK14
Gene ID: 43847
Uniprot ID: KLK14_HUMAN
Immunogen Region: 24-25
Specificity: This antibody detects endogenous levels of Human, Mouse, Rat Kallikrein-14 (Cleaved-Ile25, protein was cleaved amino acid sequence between 24-25 )
Immunogen: Synthesized peptide derived from human Kallikrein-14 (Cleaved-Ile25)
Post Translational Modifications Proteolytic cleavage of the activation peptide produces the active enzyme.
Function Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis.
Protein Name Kallikrein-14
Hk14
Kallikrein-Like Protein 6
Klk-L6
Database Links Reactome: R-HSA-6809371
Cellular Localisation Secreted
Extracellular Space
Alternative Antibody Names Anti-Kallikrein-14 antibody
Anti-Hk14 antibody
Anti-Kallikrein-Like Protein 6 antibody
Anti-Klk-L6 antibody
Anti-KLK14 antibody
Anti-KLKL6 antibody

Information sourced from Uniprot.org

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