Anti-Cleaved-KLK14-Ile25 antibody (24-25) (STJA0005882)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human Kallikrein-14 (Cleaved-Ile25)
General Information
| Short Description | Rabbit polyclonal anti-Cleaved-Kallikrein-14-Ile25 (24-25) for use in WB and IHC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-p 1:50-300 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KLK14 |
| Gene ID | 43847 |
| Uniprot ID | KLK14_HUMAN |
| Immunogen | Synthesized peptide derived from human Kallikrein-14 (Cleaved-Ile25) |
| Immunogen Region | 24-25 |
| Specificity | This antibody detects endogenous levels of Human, Mouse, Rat Kallikrein-14 (Cleaved-Ile25, protein was cleaved amino acid sequence between 24-25 ) |
Additional Info
| Post Translational Modifications | Proteolytic cleavage of the activation peptide produces the active enzyme. |
| Function | Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis. |
| Protein Name | Kallikrein-14Hk14Kallikrein-Like Protein 6Klk-L6 |
| Database Links | Reactome: R-HSA-6809371 |
| Cellular Localisation | SecretedExtracellular Space |
| Alternative Antibody Names | Anti-Kallikrein-14 antibodyAnti-Hk14 antibodyAnti-Kallikrein-Like Protein 6 antibodyAnti-Klk-L6 antibodyAnti-KLK14 antibodyAnti-KLKL6 antibody |
Information sourced from Uniprot.org