Anti-Cleaved-CTSC-R394 antibody (345-394 aa) (STJ90034)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human Dipeptidyl-peptidase 1 at the amino acid range 345-394
General Information
| Short Description | Rabbit polyclonal anti-Cleaved-Dipeptidyl peptidase 1-R394 (345-394 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CTSC |
| Gene ID | 1075 |
| Uniprot ID | CATC_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human Dipeptidyl-peptidase 1 at the amino acid range 345-394 |
| Immunogen Region | 345-394 aa |
| Specificity | Cleaved-Cathepsin C HC (R394) Polyclonal Antibody detects endogenous levels of fragment of activated Cathepsin C HC protein resulting from cleavage adjacent to R394. |
Additional Info
| Post Translational Modifications | N-glycosylated. While glycosylation at Asn-53, Asn-119 and Asn-276 is mediated by STT3A-containing complexes, glycosylation at Asn-29 is mediated STT3B-containing complexes. In approximately 50% of the complexes the exclusion domain is cleaved at position 58 or 61. The two parts of the exclusion domain are held together by a disulfide bond. |
| Function | Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B. |
| Protein Name | Dipeptidyl Peptidase 1Cathepsin CCathepsin JDipeptidyl Peptidase IDpp-IDppiDipeptidyl Transferase Cleaved Into - Dipeptidyl Peptidase 1 Exclusion Domain ChainDipeptidyl Peptidase I Exclusion Domain Chain - Dipeptidyl Peptidase 1 Heavy ChainDipeptidyl Peptidase I Heavy Chain - Dipeptidyl Peptidase 1 Light ChainDipeptidyl Peptidase I Light Chain |
| Database Links | Reactome: R-HSA-204005Reactome: R-HSA-2132295Reactome: R-HSA-5694530Reactome: R-HSA-6798695 |
| Cellular Localisation | Lysosome |
| Alternative Antibody Names | Anti-Dipeptidyl Peptidase 1 antibodyAnti-Cathepsin C antibodyAnti-Cathepsin J antibodyAnti-Dipeptidyl Peptidase I antibodyAnti-Dpp-I antibodyAnti-Dppi antibodyAnti-Dipeptidyl Transferase Cleaved Into - Dipeptidyl Peptidase 1 Exclusion Domain Chain antibodyAnti-Dipeptidyl Peptidase I Exclusion Domain Chain - Dipeptidyl Peptidase 1 Heavy Chain antibodyAnti-Dipeptidyl Peptidase I Heavy Chain - Dipeptidyl Peptidase 1 Light Chain antibodyAnti-Dipeptidyl Peptidase I Light Chain antibodyAnti-CTSC antibodyAnti-CPPI antibody |
Information sourced from Uniprot.org