| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Cleaved-Caspase-10-D415 (415-416) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:1000-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CASP10 |
| Gene ID: |
843 |
| Uniprot ID: |
CASPA_HUMAN |
| Immunogen Region: |
415-416 |
| Specificity: |
This antibody detects endogenous levels of Human Caspase-10 p23/17 (Cleaved-D415, protein was cleaved amino acid sequence between 415-416) |
| Immunogen: |
Synthesized peptide derived from human Caspase-10 p23/17 (Cleaved-D415) |
| Tissue Specificity | Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon. |
| Post Translational Modifications | Cleavage by granzyme B and autocatalytic activity generate the two active subunits. |
| Function | Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP8 and CASP9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. Isoform 7 can enhance NF-kappaB activity but promotes only slight apoptosis. Isoform C is proteolytically inactive. |
| Protein Name | Caspase-10Casp-10Apoptotic Protease Mch-4Fas-Associated Death Domain Protein Interleukin-1b-Converting Enzyme 2Flice2Ice-Like Apoptotic Protease 4 Cleaved Into - Caspase-10 Subunit P23/17 - Caspase-10 Subunit P12 |
| Database Links | Reactome: R-HSA-6803207Reactome: R-HSA-75157Reactome: R-HSA-75158Reactome: R-HSA-933543 |
| Alternative Antibody Names | Anti-Caspase-10 antibodyAnti-Casp-10 antibodyAnti-Apoptotic Protease Mch-4 antibodyAnti-Fas-Associated Death Domain Protein Interleukin-1b-Converting Enzyme 2 antibodyAnti-Flice2 antibodyAnti-Ice-Like Apoptotic Protease 4 Cleaved Into - Caspase-10 Subunit P23/17 - Caspase-10 Subunit P12 antibodyAnti-CASP10 antibodyAnti-MCH4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
