Anti-CLDN7 antibody (29-211) (STJ23163)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CLDN7 (29-211) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:5000IF/ICC:1:100-1:500ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CLDN7 |
| Gene ID | 1366 |
| Uniprot ID | CLD7_HUMAN |
| Immunogen Region | 29-211 |
| Immunogen Sequence | QWQMSSYAGDNIITAQAMYK GLWMDCVTQSTGMMSCKMYD SVLALSAALQATRALMVVSL VLGFLAMFVATMGMKCTRCG GDDKVKKARIAMGGGIIFIV AGLAALVACSWYGHQIVTDF YNPLIPTNIKYEFGPAIFIG WAGSALVILGGALLSCSCPG NESKAGYRVPRSYPKSNSSK EYV |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 29-211 of human CLDN7 (NP_001298.3). |
Additional Info
| Tissue Specificity | Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions. |
| Post Translational Modifications | Phosphorylated. |
| Function | Plays a major role in tight junction-specific obliteration of the intercellular space. |
| Protein Name | Claudin-7Cldn-7 |
| Database Links | Reactome: R-HSA-420029 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembraneCell JunctionTight JunctionCo-Localizes With Epcam At The Basolateral Cell Membrane And Tight Junction |
| Alternative Antibody Names | Anti-Claudin-7 antibodyAnti-Cldn-7 antibodyAnti-CLDN7 antibodyAnti-CEPTRL2 antibodyAnti-CPETRL2 antibody |
Information sourced from Uniprot.org