Anti-CLDN4 antibody (109-209) (STJ114778)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CLDN4 (109-209) antibody for use in WB, IHC-P and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:2000-1:4000IHC-P:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CLDN4 |
| Gene ID | 1364 |
| Uniprot ID | CLD4_HUMAN |
| Immunogen Region | 109-209 |
| Immunogen Sequence | EDESAKAKTMIVAGVVFLLA GLMVIVPVSWTAHNIIQDFY NPLVASGQKREMGASLYVGW AASGLLLLGGGLLCCNCPPR TDKPYSAKYSAARSAAASNY V |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 109-209 of human CLDN4 (NP_001296.1). |
Additional Info
| Post Translational Modifications | Phosphorylated. Phosphorylation by EPHA2 is stimulated by EFNA1 and alters interaction with TJP1. |
| Function | Can associate with other claudins to regulate tight junction structural and functional strand dynamics. May coassemble with CLDN8 into tight junction strands containing anion-selective channels that convey paracellular chloride permeability in renal collecting ducts. May integrate into CLDN3 strands to modulate localized tight junction barrier properties. May disrupt strand assembly of channel-forming CLDN2 and CLDN15 and inhibit cation conductance. Cannot form tight junction strands on its own. |
| Protein Name | Claudin-4Clostridium Perfringens Enterotoxin ReceptorCpe-RCpe-ReceptorWilliams-Beuren Syndrome Chromosomal Region 8 Protein |
| Database Links | Reactome: R-HSA-420029 |
| Cellular Localisation | Cell JunctionTight JunctionCell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Claudin-4 antibodyAnti-Clostridium Perfringens Enterotoxin Receptor antibodyAnti-Cpe-R antibodyAnti-Cpe-Receptor antibodyAnti-Williams-Beuren Syndrome Chromosomal Region 8 Protein antibodyAnti-CLDN4 antibodyAnti-CPER antibodyAnti-CPETR1 antibodyAnti-WBSCR8 antibody |
Information sourced from Uniprot.org