| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Calcium-activated chloride channel regulator 2 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CLCA2 |
| Gene ID: |
9635 |
| Uniprot ID: |
CLCA2_HUMAN |
| Specificity: |
This antibody detects endogenous levels of CLCA2 at Human, Mouse |
| Immunogen: |
Synthesized peptide derived from human CLCA2 |
| Post Translational Modifications | The 141 kDa mature form is autoproteolytically cleaved by the metalloprotease domain, producing a 109 kDa form and a 35 kDa form. The cleavage is necessary for calcium-activated chloride channel (CaCC) activation activity. N-glycosylated. |
| Function | Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4. |
| Protein Name | Calcium-Activated Chloride Channel Regulator 2Calcium-Activated Chloride Channel Family Member 2Hclca2Calcium-Activated Chloride Channel Protein 3Cacc-3Hcacc-3 Cleaved Into - Calcium-Activated Chloride Channel Regulator 2 - 109 Kda Form - Calcium-Activated Chloride Channel Regulator 2 - 35 Kda Form |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinBasal Cell MembraneCell JunctionCalcium-Activated Chloride Channel Regulator 2109 Kda Form: SecretedRemains Associated To The 35 Kda Form Until An Unidentified Event Triggers The Release |
| Alternative Antibody Names | Anti-Calcium-Activated Chloride Channel Regulator 2 antibodyAnti-Calcium-Activated Chloride Channel Family Member 2 antibodyAnti-Hclca2 antibodyAnti-Calcium-Activated Chloride Channel Protein 3 antibodyAnti-Cacc-3 antibodyAnti-Hcacc-3 Cleaved Into - Calcium-Activated Chloride Channel Regulator 2 - 109 Kda Form - Calcium-Activated Chloride Channel Regulator 2 - 35 Kda Form antibodyAnti-CLCA2 antibodyAnti-CACC3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
