Anti-CLCA2 antibody (STJA0007664)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human CLCA2
General Information
| Short Description | Rabbit polyclonal anti-Calcium-activated chloride channel regulator 2 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CLCA2 |
| Gene ID | 9635 |
| Uniprot ID | CLCA2_HUMAN |
| Immunogen | Synthesized peptide derived from human CLCA2 |
| Specificity | This antibody detects endogenous levels of CLCA2 at Human, Mouse |
Additional Info
| Post Translational Modifications | The 141 kDa mature form is autoproteolytically cleaved by the metalloprotease domain, producing a 109 kDa form and a 35 kDa form. The cleavage is necessary for calcium-activated chloride channel (CaCC) activation activity. N-glycosylated. |
| Function | Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4. |
| Protein Name | Calcium-Activated Chloride Channel Regulator 2Calcium-Activated Chloride Channel Family Member 2Hclca2Calcium-Activated Chloride Channel Protein 3Cacc-3Hcacc-3 Cleaved Into - Calcium-Activated Chloride Channel Regulator 2 - 109 Kda Form - Calcium-Activated Chloride Channel Regulator 2 - 35 Kda Form |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinBasal Cell MembraneCell JunctionCalcium-Activated Chloride Channel Regulator 2109 Kda Form: SecretedRemains Associated To The 35 Kda Form Until An Unidentified Event Triggers The Release |
| Alternative Antibody Names | Anti-Calcium-Activated Chloride Channel Regulator 2 antibodyAnti-Calcium-Activated Chloride Channel Family Member 2 antibodyAnti-Hclca2 antibodyAnti-Calcium-Activated Chloride Channel Protein 3 antibodyAnti-Cacc-3 antibodyAnti-Hcacc-3 Cleaved Into - Calcium-Activated Chloride Channel Regulator 2 - 109 Kda Form - Calcium-Activated Chloride Channel Regulator 2 - 35 Kda Form antibodyAnti-CLCA2 antibodyAnti-CACC3 antibody |
Information sourced from Uniprot.org