| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:1000-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CKB |
| Gene ID: |
1152 |
| Uniprot ID: |
KCRB_HUMAN |
| Immunogen Region: |
182-381 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 182-381 of human Creatine kinase B type (Creatine kinase B type (CKB) ) (NP_001814.2). |
| Immunogen Sequence: |
AEQQQLIDDHFLFDKPVSPL LLASGMARDWPDARGIWHND NKTFLVWVNEEDHLRVISMQ KGGNMKEVFTRFCTGLTQIE TLFKSKDYEFMWNPHLGYIL TCPSNLGTGLRAGVHIKLPN LGKHEKFSEVLKRLRLQKRG TGGVDTAAVGGVFDVSNADR LGFSEVELVQMVVDGVKLLI EMEQRLEQGQAIDDLMPAQK |
| Post Translational Modifications | Ubiquitinated by the ECS(ASB9) complex, leading to its degradation by the proteasome. |
| Function | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (Probable). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating phosphorylation of creatine to initiate a futile cycle of creatine phosphorylation and dephosphorylation. During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work. |
| Protein Name | Creatine Kinase B-TypeBrain Creatine KinaseB-CkCreatine Kinase B ChainCreatine Phosphokinase B-TypeCpk-B |
| Database Links | Reactome: R-HSA-71288Reactome: R-HSA-9696264 |
| Cellular Localisation | CytoplasmCytosolMitochondrionCell MembraneLocalizes To The Mitochondria Of Thermogenic Fat Cells Via The Internal Mts-Like Signal (Imts-L) Region |
| Alternative Antibody Names | Anti-Creatine Kinase B-Type antibodyAnti-Brain Creatine Kinase antibodyAnti-B-Ck antibodyAnti-Creatine Kinase B Chain antibodyAnti-Creatine Phosphokinase B-Type antibodyAnti-Cpk-B antibodyAnti-CKB antibodyAnti-CKBB antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
