| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CISD2 (61-135) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:100-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CISD2 |
| Gene ID: |
493856 |
| Uniprot ID: |
CISD2_HUMAN |
| Immunogen Region: |
61-135 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 61-135 of human CISD2 (NP_001008389.1). |
| Immunogen Sequence: |
PKKKQQKDSLINLKIQKENP KVVNEINIEDLCLTKAAYCR CWRSKTFPACDGSHNKHNEL TGDNVGPLILKKKEV |
| Tissue Specificity | Testis, small intestine, kidney, lung, brain, heart, pancreas and platelets. |
| Function | Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy. |
| Protein Name | Cdgsh Iron-Sulfur Domain-Containing Protein 2Endoplasmic Reticulum Intermembrane Small ProteinMitoneet-Related 1 ProteinMiner1Nutrient-Deprivation Autophagy Factor-1Naf-1 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinMitochondrion Outer MembraneIt Mainly Localizes To The Endoplasmic ReticulumHoweverExperiments In Mouse Showed That It Mainly Localizes To The Mitochondrion Outer Membrane |
| Alternative Antibody Names | Anti-Cdgsh Iron-Sulfur Domain-Containing Protein 2 antibodyAnti-Endoplasmic Reticulum Intermembrane Small Protein antibodyAnti-Mitoneet-Related 1 Protein antibodyAnti-Miner1 antibodyAnti-Nutrient-Deprivation Autophagy Factor-1 antibodyAnti-Naf-1 antibodyAnti-CISD2 antibodyAnti-CDGSH2 antibodyAnti-ERIS antibodyAnti-ZCD2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
