Anti-CISD2 antibody (61-135) (STJ116103)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CISD2 (61-135) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:100-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CISD2 |
| Gene ID | 493856 |
| Uniprot ID | CISD2_HUMAN |
| Immunogen Region | 61-135 |
| Immunogen Sequence | PKKKQQKDSLINLKIQKENP KVVNEINIEDLCLTKAAYCR CWRSKTFPACDGSHNKHNEL TGDNVGPLILKKKEV |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 61-135 of human CISD2 (NP_001008389.1). |
Additional Info
| Tissue Specificity | Testis, small intestine, kidney, lung, brain, heart, pancreas and platelets. |
| Function | Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy. |
| Protein Name | Cdgsh Iron-Sulfur Domain-Containing Protein 2Endoplasmic Reticulum Intermembrane Small ProteinMitoneet-Related 1 ProteinMiner1Nutrient-Deprivation Autophagy Factor-1Naf-1 |
| Database Links | |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinMitochondrion Outer MembraneIt Mainly Localizes To The Endoplasmic ReticulumHoweverExperiments In Mouse Showed That It Mainly Localizes To The Mitochondrion Outer Membrane |
| Alternative Antibody Names | Anti-Cdgsh Iron-Sulfur Domain-Containing Protein 2 antibodyAnti-Endoplasmic Reticulum Intermembrane Small Protein antibodyAnti-Mitoneet-Related 1 Protein antibodyAnti-Miner1 antibodyAnti-Nutrient-Deprivation Autophagy Factor-1 antibodyAnti-Naf-1 antibodyAnti-CISD2 antibodyAnti-CDGSH2 antibodyAnti-ERIS antibodyAnti-ZCD2 antibody |
Information sourced from Uniprot.org