Host: | Rabbit |
Applications: | WB/ELISA |
Reactivity: | Human/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
Purification: | Affinity purification |
Concentration: | Lot specific |
Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | UTP4 |
Gene ID: | 84916 |
Uniprot ID: | UTP4_HUMAN |
Immunogen Region: | 497-686 |
Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 497-686 of human CIRH1A (NP_116219.2). |
Immunogen Sequence: | NWLAASGTSAGVHVYNVKQL KLHCTVPAYNFPVTAMAIAP NTNNLVIAHSDQQVFEYSIP DKQYTDWSRTVQKQGFHHLW LQRDTPITHISFHPKRPMHI LLHDAYMFCIIDKSLPLPND KTLLYNPFPPTNESDVIRRR TAHAFKISKIYKPLLFMDLL DERTLVAVERPLDDIIAQLP PPIKKKKFGT |
Post Translational Modifications | May be phosphorylated during mitosis.may control the association of this protein with WRD43 and UTP15. |
Function | Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted d Involved in SSU pre-rRNA processing at sites A', A0, 1 and 2b. Required for optimal pre-ribosomal RNA transcription by RNA polymerase. May be a transcriptional regulator. (Microbial infection) Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5'-GGGACTTTCC-3' found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV. |
Protein Name | U3 Small Nucleolar Rna-Associated Protein 4 Homolog Cirhin Utp4 Small Subunit Processome Component |
Database Links | Reactome: R-HSA-6790901 Reactome: R-HSA-6791226 |
Cellular Localisation | Nucleus Nucleolus Chromosome Found Predominantly At The Fibrillar Center |
Alternative Antibody Names | Anti-U3 Small Nucleolar Rna-Associated Protein 4 Homolog antibody Anti-Cirhin antibody Anti-Utp4 Small Subunit Processome Component antibody Anti-UTP4 antibody Anti-CIRH1A antibody Anti-cPERP-E antibody Anti-KIAA1988 antibody |
Information sourced from Uniprot.org