| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CIRH1A (497-686) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
UTP4 |
| Gene ID: |
84916 |
| Uniprot ID: |
UTP4_HUMAN |
| Immunogen Region: |
497-686 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 497-686 of human CIRH1A (NP_116219.2). |
| Immunogen Sequence: |
NWLAASGTSAGVHVYNVKQL KLHCTVPAYNFPVTAMAIAP NTNNLVIAHSDQQVFEYSIP DKQYTDWSRTVQKQGFHHLW LQRDTPITHISFHPKRPMHI LLHDAYMFCIIDKSLPLPND KTLLYNPFPPTNESDVIRRR TAHAFKISKIYKPLLFMDLL DERTLVAVERPLDDIIAQLP PPIKKKKFGT |
| Post Translational Modifications | May be phosphorylated during mitosis.may control the association of this protein with WRD43 and UTP15. |
| Function | Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted d Involved in SSU pre-rRNA processing at sites A', A0, 1 and 2b. Required for optimal pre-ribosomal RNA transcription by RNA polymerase. May be a transcriptional regulator. (Microbial infection) Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5'-GGGACTTTCC-3' found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV. |
| Protein Name | U3 Small Nucleolar Rna-Associated Protein 4 HomologCirhinUtp4 Small Subunit Processome Component |
| Database Links | Reactome: R-HSA-6790901Reactome: R-HSA-6791226 |
| Cellular Localisation | NucleusNucleolusChromosomeFound Predominantly At The Fibrillar Center |
| Alternative Antibody Names | Anti-U3 Small Nucleolar Rna-Associated Protein 4 Homolog antibodyAnti-Cirhin antibodyAnti-Utp4 Small Subunit Processome Component antibodyAnti-UTP4 antibodyAnti-CIRH1A antibodyAnti-cPERP-E antibodyAnti-KIAA1988 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
