| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CHRNA10 |
| Gene ID: | 57053 |
| Uniprot ID: | ACH10_HUMAN |
| Immunogen Region: | 25-240 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-240 of human CHRNA10 (NP_065135.2). |
| Immunogen Sequence: | AEGRLALKLFRDLFANYTSA LRPVADTDQTLNVTLEVTLS QIIDMDERNQVLTLYLWIRQ EWTDAYLRWDPNAYGGLDAI RIPSSLVWRPDIVLYNKADA QPPGSASTNVVLRHDGAVRW DAPAITRSSCRVDVAAFPFD AQHCGLTFGSWTHGGHQLDV RPRGAAASLADFVENVEWRV LGMPARRRVLTYGCCSEPYP DVTFTLLLRRRAAAYV |
| Tissue Specificity | Expressed in inner-ear tissue, tonsil, immortalized B-cells, cultured T-cells and peripheral blood lymphocytes. |
| Function | Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. |
| Protein Name | Neuronal Acetylcholine Receptor Subunit Alpha-10 Nicotinic Acetylcholine Receptor Subunit Alpha-10 Nachr Alpha-10 |
| Database Links | Reactome: R-HSA-9667769 |
| Cellular Localisation | Postsynaptic Cell Membrane Multi-Pass Membrane Protein Cell Membrane |
| Alternative Antibody Names | Anti-Neuronal Acetylcholine Receptor Subunit Alpha-10 antibody Anti-Nicotinic Acetylcholine Receptor Subunit Alpha-10 antibody Anti-Nachr Alpha-10 antibody Anti-CHRNA10 antibody Anti-NACHRA10 antibody |
Information sourced from Uniprot.org