| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CHRNA10 (25-240) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CHRNA10 |
| Gene ID: |
57053 |
| Uniprot ID: |
ACH10_HUMAN |
| Immunogen Region: |
25-240 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 25-240 of human CHRNA10 (NP_065135.2). |
| Immunogen Sequence: |
AEGRLALKLFRDLFANYTSA LRPVADTDQTLNVTLEVTLS QIIDMDERNQVLTLYLWIRQ EWTDAYLRWDPNAYGGLDAI RIPSSLVWRPDIVLYNKADA QPPGSASTNVVLRHDGAVRW DAPAITRSSCRVDVAAFPFD AQHCGLTFGSWTHGGHQLDV RPRGAAASLADFVENVEWRV LGMPARRRVLTYGCCSEPYP DVTFTLLLRRRAAAYV |
| Tissue Specificity | Expressed in inner-ear tissue, tonsil, immortalized B-cells, cultured T-cells and peripheral blood lymphocytes. |
| Function | Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. |
| Protein Name | Neuronal Acetylcholine Receptor Subunit Alpha-10Nicotinic Acetylcholine Receptor Subunit Alpha-10Nachr Alpha-10 |
| Database Links | Reactome: R-HSA-9667769 |
| Cellular Localisation | Postsynaptic Cell MembraneMulti-Pass Membrane ProteinCell Membrane |
| Alternative Antibody Names | Anti-Neuronal Acetylcholine Receptor Subunit Alpha-10 antibodyAnti-Nicotinic Acetylcholine Receptor Subunit Alpha-10 antibodyAnti-Nachr Alpha-10 antibodyAnti-CHRNA10 antibodyAnti-NACHRA10 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
