Anti-CHI3L1 antibody (STJ193191)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human GP-39
General Information
| Short Description | Rabbit polyclonal anti-Chitinase-3-like protein 1 for use in IHC, IF and WB in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF/WB |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC-P 1:50-200WB 1:500-2000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CHI3L1 |
| Gene ID | 1116 |
| Uniprot ID | CH3L1_HUMAN |
| Immunogen | Synthesized peptide derived from the human GP-39 |
| Specificity | This antibody detects endogenous levels of human GP-39 |
Additional Info
| Post Translational Modifications | Glycosylated. |
| Function | Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung. |
| Protein Name | Chitinase-3-Like Protein 139 Kda Synovial ProteinCartilage Glycoprotein 39Cgp-39Gp-39Hcgp-39Ykl-40 |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | SecretedExtracellular SpaceCytoplasmPerinuclear RegionEndoplasmic Reticulum |
| Alternative Antibody Names | Anti-Chitinase-3-Like Protein 1 antibodyAnti-39 Kda Synovial Protein antibodyAnti-Cartilage Glycoprotein 39 antibodyAnti-Cgp-39 antibodyAnti-Gp-39 antibodyAnti-Hcgp-39 antibodyAnti-Ykl-40 antibodyAnti-CHI3L1 antibody |
Information sourced from Uniprot.org