Anti-CHAC1 antibody (1-222) (STJ118037)

Name: Anti-CHAC1 antibody (1-222) (STJ118037)
SKU: STJ118037
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ118037

Current Stock:

🚚 Free UK Delivery on orders over £150

Quantity:

Processing The item has been added

Enquire For Bulk Order

✓ 1-Year Performance Guarantee | SDS & Datasheet Included | Expert Tech Support | Covered by St John's Laboratory Guarantee

Short Description	Rabbit polyclonal CHAC1 (1-222) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IHC-P/IF/ICC/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:1000 IHC-P:1:50-1:200 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	CHAC1
Gene ID	79094
Uniprot ID	CHAC1_HUMAN
Immunogen Region	1-222
Immunogen Sequence	MKQESAAPNTPPTSQSPTPS AQFPRNDGDPQALWIFGYGS LVWRPDFAYSDSRVGFVRGY SRRFWQGDTFHRGSDKMPGR VVTLLEDHEGCTWGVAYQVQ GEQVSKALKYLNVREAVLGG YDTKEVTFYPQDAPDQPLKA LAYVATPQNPGYLGPAPEEA IATQILACRGFSGHNLEYLL RLADFMQLCGPQAQDEHLAA IVDAVGTMLPCFCPTEQALA LV
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 1-222 of human CHAC1 (NP_077016.3).

Function	Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade. Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos.
Protein Name	Glutathione-Specific Gamma-Glutamylcyclotransferase 1 Gamma-Gcg 1 Blocks Notch Protein Botch Cation Transport Regulator-Like Protein 1
Database Links	Reactome: R-HSA-174403 Reactome: R-HSA-9648895
Cellular Localisation	Cytoplasm Cytosol Golgi Apparatus Trans-Golgi Network
Alternative Antibody Names	Anti-Glutathione-Specific Gamma-Glutamylcyclotransferase 1 antibody Anti-Gamma-Gcg 1 antibody Anti-Blocks Notch Protein antibody Anti-Botch antibody Anti-Cation Transport Regulator-Like Protein 1 antibody Anti-CHAC1 antibody Anti-BOTCH antibody

Information sourced from Uniprot.org