| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CFB (80-420) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CFB |
| Gene ID: |
629 |
| Uniprot ID: |
CFAB_HUMAN |
| Immunogen Region: |
80-420 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 80-420 of human Complement factor B (CFB) (NP_001701.2). |
| Immunogen Sequence: |
GSWSTLKTQDQKTVRKAECR AIHCPRPHDFENGEYWPRSP YYNVSDEISFHCYDGYTLRG SANRTCQVNGRWSGQTAICD NGAGYCSNPGIPIGTRKVGS QYRLEDSVTYHCSRGLTLRG SQRRTCQEGGSWSGTEPSCQ DSFMYDTPQEVAEAFLSSLT ETIEGVDAEDGHGPGEQQKR KIVLDPSGSMNIYLVLDGSD SIGASNFTGAKKCLVNLIEK VASYGVKPRYGLVTYATYP |
| Function | Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes. |
| Protein Name | Complement Factor BC3/C5 ConvertaseGlycine-Rich Beta GlycoproteinGbgPbf2Properdin Factor B Cleaved Into - Complement Factor B Ba Fragment - Complement Factor B Bb Fragment |
| Database Links | Reactome: R-HSA-173736Reactome: R-HSA-174577Reactome: R-HSA-977606 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Complement Factor B antibodyAnti-C3/C5 Convertase antibodyAnti-Glycine-Rich Beta Glycoprotein antibodyAnti-Gbg antibodyAnti-Pbf2 antibodyAnti-Properdin Factor B Cleaved Into - Complement Factor B Ba Fragment - Complement Factor B Bb Fragment antibodyAnti-CFB antibodyAnti-BF antibodyAnti-BFD antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
