Anti-CERT1 antibody (STJA0007958)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human COL4A3BP
General Information
| Short Description | Rabbit polyclonal anti-Ceramide transfer protein for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CERT1 |
| Gene ID | 10087 |
| Uniprot ID | CERT_HUMAN |
| Immunogen | Synthesized peptide derived from human COL4A3BP |
| Specificity | This antibody detects endogenous levels of COL4A3BP at Human, Mouse |
Additional Info
| Post Translational Modifications | Phosphorylation on Ser-132 decreases the affinity toward phosphatidylinositol 4-phosphate at Golgi membranes and reduces ceramide transfer activity. Inactivated by hyperphosphorylation of serine residues by CSNK1G2/CK1 that triggers dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. |
| Function | Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner. |
| Protein Name | Ceramide Transfer ProteinHcertCollagen Type Iv Alpha-3-Binding ProteinGoodpasture Antigen-Binding ProteinGpbpStart Domain-Containing Protein 11Stard11Star-Related Lipid Transfer Protein 11 |
| Database Links | Reactome: R-HSA-1660661 Q9Y5P4-2 |
| Cellular Localisation | CytoplasmGolgi ApparatusEndoplasmic ReticulumPreferentially Localized To The Golgi Apparatus |
| Alternative Antibody Names | Anti-Ceramide Transfer Protein antibodyAnti-Hcert antibodyAnti-Collagen Type Iv Alpha-3-Binding Protein antibodyAnti-Goodpasture Antigen-Binding Protein antibodyAnti-Gpbp antibodyAnti-Start Domain-Containing Protein 11 antibodyAnti-Stard11 antibodyAnti-Star-Related Lipid Transfer Protein 11 antibodyAnti-CERT1 antibodyAnti-CERT antibodyAnti-COL4A3BP antibodyAnti-STARD11 antibody |
Information sourced from Uniprot.org