| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CERK |
| Gene ID: | 64781 |
| Uniprot ID: | CERK1_HUMAN |
| Immunogen Region: | C-Term |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 400 to the C-terminus of human CERK (NP_073603.2). |
| Immunogen Sequence: | CRRSPRGLSPAAHLGDGSSD LILIRKCSRFNFLRFLIRHT NQQDQFDFTFVEVYRVKKFQ FTSKHMEDEDSDLKEGGKKR FGHICSSHPSCCCTVSNSSW NCDGEVLHSPAIEVRVHCQL VRLFARGIEENPKPDSHS |
| Tissue Specificity | High level expression in heart, brain, skeletal muscle, kidney and liver.moderate in peripheral blood leukocytes and thymus.very low in spleen, small intestine, placenta and lung. |
| Function | Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Shows a greater preference for D-erythro isomer of ceramides. Binds phosphoinositides. |
| Protein Name | Ceramide KinaseHcerkAcylsphingosine KinaseLipid Kinase 4Lk4 |
| Database Links | Reactome: R-HSA-9840309 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Ceramide Kinase antibodyAnti-Hcerk antibodyAnti-Acylsphingosine Kinase antibodyAnti-Lipid Kinase 4 antibodyAnti-Lk4 antibodyAnti-CERK antibodyAnti-KIAA1646 antibody |
Information sourced from Uniprot.org