Anti-CDH23/USH1D antibody (Internal) (STJ71691)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-CDH23/USH1D (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:1000.WB: Approx 60kDa band observed in Human Brain (Amygdala and Frontal Cortex lysates (calculated MW of 58.6kDa according to NP_443068.1). Recommended concentration: 1-3µg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | CDH23 |
| Gene ID | 64072 |
| Uniprot ID | CAD23_HUMAN |
| Accession Number | NP_071407.3; NP_443068.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | YNISLYENVTVGTS |
| Specificity | This antibody is expected to recognize both reported isoforms (NP_071407.3; NP_443068.1). |
Additional Info
| Function | Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. |
| Protein Name | Cadherin-23Otocadherin |
| Database Links | Reactome: R-HSA-9662360Reactome: R-HSA-9662361 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Cadherin-23 antibodyAnti-Otocadherin antibodyAnti-CDH23 antibodyAnti-KIAA1774 antibodyAnti-KIAA1812 antibodyAnti-UNQ1894 antibodyAnti-PRO4340 antibody |
Information sourced from Uniprot.org