Anti-CDCA2 antibody (511-560 aa) (STJ95418)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human CDCA2 at the amino acid range 511-560
General Information
| Short Description | Rabbit polyclonal anti-Cell division cycle-associated protein 2 (511-560 aa) for use in WB, IHC, IF and ELISA in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:5000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CDCA2 |
| Gene ID | 157313 |
| Uniprot ID | CDCA2_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human CDCA2 at the amino acid range 511-560 |
| Immunogen Region | 511-560 aa |
| Specificity | Repo-Man Polyclonal Antibody detects endogenous levels of Repo-Man protein. |
Additional Info
| Post Translational Modifications | Phosphorylated by CDK1. May regulate its subcellular location. |
| Function | Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. |
| Protein Name | Cell Division Cycle-Associated Protein 2Recruits Pp1 Onto Mitotic Chromatin At Anaphase ProteinRepo-Man |
| Database Links | |
| Cellular Localisation | NucleusExcluded From The NucleolusPresent In Nucleoplasm Throughout The G1S And G2 Stages Of The Cell CycleDuring M PhaseIt Becomes Diffuse Throughout The Cell As The Nuclear Membrane Breaks DownAnd Faintly Accumulates Later On Metaphase ChromatinAs The Cell Progresses To AnaphaseIt Accumulates On Chromatin |
| Alternative Antibody Names | Anti-Cell Division Cycle-Associated Protein 2 antibodyAnti-Recruits Pp1 Onto Mitotic Chromatin At Anaphase Protein antibodyAnti-Repo-Man antibodyAnti-CDCA2 antibody |
Information sourced from Uniprot.org