Anti-CDC42SE2 antibody (3-53 aa) (STJ196184)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human C42S2 at the amino acid range 3-53
General Information
| Short Description | Rabbit polyclonal anti-CDC42 small effector protein 2 (3-53 aa) for use in IHC and IF in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC-P 1:50-200IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CDC42SE2 |
| Gene ID | 56990 |
| Uniprot ID | C42S2_HUMAN |
| Immunogen | Synthesized peptide derived from the human C42S2 at the amino acid range 3-53 |
| Immunogen Region | 3-53 aa |
| Specificity | This antibody detects endogenous levels of C42S2 at Human/Mouse/Rat |
Additional Info
| Function | Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages. |
| Protein Name | Cdc42 Small Effector Protein 2Small Effector Of Cdc42 Protein 2 |
| Database Links | Reactome: R-HSA-9013148 |
| Cellular Localisation | CytoplasmCytoskeletonCell MembraneLipid-AnchorCell ProjectionPhagocytic CupRecruited To The Activated Tcr Prior Actin PolymerizationLocalizes At The Phagocytic Cup Of Macrophages |
| Alternative Antibody Names | Anti-Cdc42 Small Effector Protein 2 antibodyAnti-Small Effector Of Cdc42 Protein 2 antibodyAnti-CDC42SE2 antibodyAnti-SPEC2 antibody |
Information sourced from Uniprot.org