| Host: |
Rabbit |
| Applications: |
IHC/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CDC42 small effector protein 2 (3-53 aa) is suitable for use in Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
IHC-P 1:50-200IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CDC42SE2 |
| Gene ID: |
56990 |
| Uniprot ID: |
C42S2_HUMAN |
| Immunogen Region: |
3-53 aa |
| Specificity: |
This antibody detects endogenous levels of C42S2 at Human/Mouse/Rat |
| Immunogen: |
Synthesized peptide derived from the human C42S2 at the amino acid range 3-53 |
| Function | Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages. |
| Protein Name | Cdc42 Small Effector Protein 2Small Effector Of Cdc42 Protein 2 |
| Database Links | Reactome: R-HSA-9013148 |
| Cellular Localisation | CytoplasmCytoskeletonCell MembraneLipid-AnchorCell ProjectionPhagocytic CupRecruited To The Activated Tcr Prior Actin PolymerizationLocalizes At The Phagocytic Cup Of Macrophages |
| Alternative Antibody Names | Anti-Cdc42 Small Effector Protein 2 antibodyAnti-Small Effector Of Cdc42 Protein 2 antibodyAnti-CDC42SE2 antibodyAnti-SPEC2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
