| Host: |
Rabbit |
| Applications: |
WB/FC/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Monoclonal |
| Clone ID: |
S5206RM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000FC:1:100-1:500ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
Cd80 |
| Gene ID: |
12519 |
| Uniprot ID: |
CD80_MOUSE |
| Immunogen Region: |
38-245 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 38-245 of mouse CD80 (NP_033985.3) |
| Immunogen Sequence: |
VDEQLSKSVKDKVLLPCRYN SPHEDESEDRIYWQKHDKVV LSVIAGKLKVWPEYKNRTLY DNTTYSLIILGLVLSDRGTY SCVVQKKERGTYEVKHLALV KLSIKADFSTPNITESGNPS ADTKRITCFASGGFPKPRFS WLENGRELPGINTTISQDPE SELYTISSQLDFNTTRNHTI KCLIKYGDAHVSEDFTWEKP PEDPPDSK |
| Tissue Specificity | Expressed on activated B-cells, gamma interferon stimulated monocytes and non-circulating B-cell malignancies. |
| Function | Costimulatory molecule that belongs to the immunoglobulin superfamily that plays an important role in T-lymphocyte activation. Acts as the primary auxiliary signal augmenting the MHC/TCR signal in naive T-cells together with the CD28 receptor which is constitutively expressed on the cell surface of T-cells. In turn, activates different signaling pathways such as NF-kappa-B or MAPK leading to the production of different cytokines. In addition, CD28/CD80 costimulatory signal stimulates glucose metabolism and ATP synthesis of T-cells by activating the PI3K/Akt signaling pathway. Acts also as a regulator of PDL1/PDCD1 interactions to limit excess engagement of PDL1 and its inhibitory role in immune responses. Expressed on B-cells, plays a critical role in regulating interactions between B-cells and T-cells in both early and late germinal center responses, which are crucial for the generation of effective humoral immune responses. |
| Protein Name | T-Lymphocyte Activation Antigen Cd80Activation B7-1 AntigenB7Cd Antigen Cd80 |
| Database Links | Reactome: R-MMU-1257604Reactome: -MMU-389356Reactome: -MMU-389357Reactome: -MMU-389359Reactome: -MMU-389513Reactome: -MMU-6811558 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-T-Lymphocyte Activation Antigen Cd80 antibodyAnti-Activation B7-1 Antigen antibodyAnti-B7 antibodyAnti-Cd Antigen Cd80 antibodyAnti-Cd80 antibodyAnti-B7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
