Anti-CD72 antibody (120-359) (STJ111971)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CD72 (120-359) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CD72 |
| Gene ID | 971 |
| Uniprot ID | CD72_HUMAN |
| Immunogen Region | 120-359 |
| Immunogen Sequence | QVSQQLQQTNRVLEVTNSSL RQQLRLKITQLGQSAEDLQG SRRELAQSQEALQVEQRAHQ AAEGQLQACQADRQKTKETL QSEEQQRRALEQKLSNMENR LKPFFTCGSADTCCPSGWIM HQKSCFYISLTSKNWQESQK QCETLSSKLATFSEIYPQSH SYYFLNSLLPNGGSGNSYWT GLSSNKDWKLTDDTQRTRTY AQSSKCNKVHKTWSWWTLES ESCRSSLPYICEMTAFRFP |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 120-359 of human CD72 (NP_001773.1). |
Additional Info
| Tissue Specificity | Pre-B-cells and B-cells but not terminally differentiated plasma cells. |
| Post Translational Modifications | Phosphorylated upon engagement of the B-cell receptor, probably by LYN or SYK. Phosphorylation at Tyr-7 is important for interaction with PTPN6/SHP-1. |
| Function | Co-receptor of B cell receptor (BCR) that plays both positive and negative roles on B-cell functions. Recognizes the Sm/ribonucleoprotein (RNP) self-antigen ligand, and coligation of CD72 and BCR inhibits BCR signaling. Mechanistically, ligand binding leads to the recruitment of PTPN6/SHP-1 to the BCR complex which is inhibitory to BCR signaling. Also acts as a ligand for CD5 and thereby plays a critical role in maintaining regulatory T and B-cell homeostasis. |
| Protein Name | B-Cell Differentiation Antigen Cd72Lyb-2Cd Antigen Cd72 |
| Database Links | Reactome: R-HSA-416700 |
| Cellular Localisation | MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-B-Cell Differentiation Antigen Cd72 antibodyAnti-Lyb-2 antibodyAnti-Cd Antigen Cd72 antibodyAnti-CD72 antibody |
Information sourced from Uniprot.org