![Anti-CD63 antibody [MEM-259] (STJ16100870)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/149587/346882/STJ16100870_1__45294.1681999048.jpg?c=1 "Anti-CD63 antibody [MEM-259] (STJ16100870)")
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![Anti-CD63 antibody [MEM-259] (STJ16100870)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/149587/346882/STJ16100870_1__45294.1681999048.jpg?c=1 "Anti-CD63 antibody [MEM-259] (STJ16100870)")
| Short Description : | Mouse monoclonal anti-CD63 for use in FC, IP, IHC-P and ICC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | FC/IP/IHC-P/ICC |
| Host: | Mouse |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | MEM-259 |
| Isotype: | IgG1 |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Formulation: | Phosphate buffered saline (PBS) solution with 15 mM sodium azide |
| Storage Instruction: | Store at 2-8°C for up to 1-year, upon receipt. |
| Gene Symbol: | CD63 |
| Gene ID: | 967 |
| Uniprot ID: | CD63_HUMAN |
| Immunogen: | HPB-ALL T cell line |
| Tissue Specificity | Detected in platelets (at protein level). Dysplastic nevi, radial growth phase primary melanomas, hematopoietic cells, tissue macrophages. |
| Post Translational Modifications | Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro). |
| Function | Functions as a cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli. |
| Protein Name | Cd63 AntigenGranulophysinLysosomal-Associated Membrane Protein 3Lamp-3Lysosome Integral Membrane Protein 1Limp1Melanoma-Associated Antigen Me491Oma81hOcular Melanoma-Associated AntigenTetraspanin-30Tspan-30Cd Antigen Cd63 |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinLysosome MembraneLate Endosome MembraneEndosomeMultivesicular BodyMelanosomeSecretedExtracellular ExosomeCell SurfaceAlso Found In Weibel-Palade Bodies Of Endothelial CellsLocated In Platelet Dense GranulesDetected In A Subset Of Pre-MelanosomesDetected On Intralumenal Vesicles (Ilvs) Within Multivesicular Bodies |
| Alternative Antibody Names | Anti-Cd63 Antigen antibodyAnti-Granulophysin antibodyAnti-Lysosomal-Associated Membrane Protein 3 antibodyAnti-Lamp-3 antibodyAnti-Lysosome Integral Membrane Protein 1 antibodyAnti-Limp1 antibodyAnti-Melanoma-Associated Antigen Me491 antibodyAnti-Oma81h antibodyAnti-Ocular Melanoma-Associated Antigen antibodyAnti-Tetraspanin-30 antibodyAnti-Tspan-30 antibodyAnti-Cd Antigen Cd63 antibodyAnti-CD63 antibodyAnti-MLA1 antibodyAnti-TSPAN30 antibody |
Information sourced from Uniprot.org
![Anti-CD63 antibody [MEM-259] {FITC} (STJ16100871)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/149588/346886/STJ16100871_1__53323.1681999051.jpg?c=1 "Anti-CD63 antibody [MEM-259] {FITC} (STJ16100871)")
