• Anti-CD63 antibody [MEM-259] (STJ16100870)
  • Anti-CD63 antibody [MEM-259] (STJ16100870)
  • Anti-CD63 antibody [MEM-259] (STJ16100870)
  • Anti-CD63 antibody [MEM-259] (STJ16100870)

Anti-CD63 antibody [MEM-259] (STJ16100870)

SKU:
STJ16100870-01

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Host: Mouse
Applications: FC/IP/IHC-P/ICC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-CD63 is suitable for use in Flow Cytometry, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry research applications.
Clonality: Monoclonal
Clone ID: MEM-259
Conjugation: Unconjugated
Isotype: IgG1
Formulation: Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Concentration: 1 mg/mL
Storage Instruction: Store at 2-8°C upon receipt.
Gene Symbol: CD63
Gene ID: 967
Uniprot ID: CD63_HUMAN
Immunogen: HPB-ALL T cell line
Tissue Specificity Detected in platelets (at protein level). Dysplastic nevi, radial growth phase primary melanomas, hematopoietic cells, tissue macrophages.
Post Translational Modifications Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro).
Function Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
Protein Name Cd63 Antigen
Granulophysin
Lysosomal-Associated Membrane Protein 3
Lamp-3
Lysosome Integral Membrane Protein 1
Limp1
Melanoma-Associated Antigen Me491
Oma81h
Ocular Melanoma-Associated Antigen
Tetraspanin-30
Tspan-30
Cd Antigen Cd63
Database Links Reactome: R-HSA-114608
Reactome: R-HSA-6798695
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Lysosome Membrane
Late Endosome Membrane
Endosome
Multivesicular Body
Melanosome
Secreted
Extracellular Exosome
Cell Surface
Also Found In Weibel-Palade Bodies Of Endothelial Cells
Located In Platelet Dense Granules
Detected In A Subset Of Pre-Melanosomes
Detected On Intralumenal Vesicles (Ilvs) Within Multivesicular Bodies
Alternative Antibody Names Anti-Cd63 Antigen antibody
Anti-Granulophysin antibody
Anti-Lysosomal-Associated Membrane Protein 3 antibody
Anti-Lamp-3 antibody
Anti-Lysosome Integral Membrane Protein 1 antibody
Anti-Limp1 antibody
Anti-Melanoma-Associated Antigen Me491 antibody
Anti-Oma81h antibody
Anti-Ocular Melanoma-Associated Antigen antibody
Anti-Tetraspanin-30 antibody
Anti-Tspan-30 antibody
Anti-Cd Antigen Cd63 antibody
Anti-CD63 antibody
Anti-MLA1 antibody
Anti-TSPAN30 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance