| Host: | Mouse |
| Applications: | FC/FUNC/WB/IHC |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-CD54-ICAM-1 is suitable for use in Flow Cytometry, FUNC, Western Blot and Immunohistochemistry research applications. |
| Clonality : | Monoclonal |
| Clone ID : | EBS-CD-031 |
| Conjugation: | Unconjugated |
| Isotype: | IgG2bk |
| Formulation: | PBS with 0.02% Sodium Azide. |
| Purification: | Affinity purified from tissue culture. |
| Concentration: | Can be provided as 100 µg/mL, 500 µg/mL or 1mg/mL. |
| Dilution Range: | Flow cytometry (0, 5-1, 0 µg/million cells in 0, 1 ml). Functional studies (0, 02-2, 0 µg/ml without azide). Immunoblotting (0, 5-1, 0 µg/ml). Immunohistology (2-4 µg/ml for 30 min at RT; staining of formalin-fixed tissue requires boiling tissue sect |
| Storage Instruction: | Store for up to 1 year at 2-8°C upon receipt. |
| Gene Symbol: | ICAM1 |
| Gene ID: | 3383 |
| Uniprot ID: | ICAM1_HUMAN |
| Immunogen: | A BALB/c mouse was immunized with Raji Burkitt lymphoma cells. Fusion partner: NS-1. |
| Function | ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. (Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins. (Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins. (Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell. |
| Protein Name | Intercellular Adhesion Molecule 1Icam-1Major Group Rhinovirus ReceptorCd Antigen Cd54 |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-216083Reactome: R-HSA-6783783Reactome: R-HSA-6785807Reactome: R-HSA-877300 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Intercellular Adhesion Molecule 1 antibodyAnti-Icam-1 antibodyAnti-Major Group Rhinovirus Receptor antibodyAnti-Cd Antigen Cd54 antibodyAnti-ICAM1 antibody |
Information sourced from Uniprot.org
