Anti-CD54-ICAM-1 antibody [EBS-CD-031] (STJ16101887)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2bk
ImmunogenA BALB/c mouse was immunized with Raji Burkitt lymphoma cells. Fusion partner: NS-1.
General Information
| Short Description | Mouse monoclonal anti-CD54-ICAM-1 for use in FC, FUNC, WB and IHC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC/FUNC/WB/IHC |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | EBS-CD-031 |
| Isotype | IgG2bk |
| Conjugation | Unconjugated |
| Concentration | Can be provided as 100 µg/mL, 500 µg/mL or 1mg/mL. |
| Purification | Affinity purified from tissue culture. |
| Dilution Range | Flow cytometry (0, 5-1, 0 µg/million cells in 0, 1 ml). Functional studies (0, 02-2, 0 µg/ml without azide). Immunoblotting (0, 5-1, 0 µg/ml). Immunohistology (2-4 µg/ml for 30 min at RT; staining of formalin-fixed tissue requires boiling tissue sect |
| Formulation | PBS with 0.02% Sodium Azide. |
| Storage Instruction | Store for up to 1 year at 2-8°C upon receipt. |
Target Information
| Gene Symbol | ICAM1 |
| Gene ID | 3383 |
| Uniprot ID | ICAM1_HUMAN |
| Immunogen | A BALB/c mouse was immunized with Raji Burkitt lymphoma cells. Fusion partner: NS-1. |
Additional Info
| Function | ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. (Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins. (Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins. (Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell. |
| Protein Name | Intercellular Adhesion Molecule 1Icam-1Major Group Rhinovirus ReceptorCd Antigen Cd54 |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-216083Reactome: R-HSA-6783783Reactome: R-HSA-6785807Reactome: R-HSA-877300 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Intercellular Adhesion Molecule 1 antibodyAnti-Icam-1 antibodyAnti-Major Group Rhinovirus Receptor antibodyAnti-Cd Antigen Cd54 antibodyAnti-ICAM1 antibody |
Information sourced from Uniprot.org