Anti-CD45/PTPRC nanobody [2H5] (STJN000621)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-8His-Cys-tag
General Information
| Short Description | Alpaca monoclonal nanobody anti-CD45/PTPRC is suitable for use in ELISA and SPR research applications. |
| Applications | ELISA/SPR |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 2H5 |
| Isotype | VHH-8His-Cys-tag |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Protein A/G purified from cell culture supernatant. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
Target Information
| Gene Symbol | Ptprc |
| Gene ID | 19264 |
| Uniprot ID | PTPRC_MOUSE |
Additional Info
| Function | Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity. Interacts with CLEC10A at antigen presenting cell-T cell contact.CLEC10A on immature dendritic cells recognizes Tn antigen-carrying PTPRC/CD45 receptor on effector T cells and modulates T cell activation threshold to limit autoreactivity. |
| Protein Name | Receptor-Type Tyrosine-Protein Phosphatase CLeukocyte Common AntigenL-CaLymphocyte Antigen 5Ly-5T200Cd Antigen Cd45 |
| Database Links | Reactome: R-MMU-202427Reactome: -MMU-416700Reactome: -MMU-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinMembrane RaftSynapseColocalized With Dpp4 In Membrane Rafts |
| Alternative Nanobody Names | Anti-Receptor-Type Tyrosine-Protein Phosphatase C nanobodyAnti-Leukocyte Common Antigen nanobodyAnti-L-Ca nanobodyAnti-Lymphocyte Antigen 5 nanobodyAnti-Ly-5 nanobodyAnti-T200 nanobodyAnti-Cd Antigen Cd45 nanobodyAnti-Ptprc nanobodyAnti-Ly-5 nanobody |
Information sourced from Uniprot.org