| Function | Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity. Interacts with CLEC10A at antigen presenting cell-T cell contact.CLEC10A on immature dendritic cells recognizes Tn antigen-carrying PTPRC/CD45 receptor on effector T cells and modulates T cell activation threshold to limit autoreactivity. |
| Protein Name | Receptor-Type Tyrosine-Protein Phosphatase CLeukocyte Common AntigenL-CaLymphocyte Antigen 5Ly-5T200Cd Antigen Cd45 |
| Database Links | Reactome: R-MMU-202427Reactome: -MMU-416700Reactome: -MMU-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinMembrane RaftSynapseColocalized With Dpp4 In Membrane Rafts |
| Alternative Nanobody Names | Anti-Receptor-Type Tyrosine-Protein Phosphatase C nanobodyAnti-Leukocyte Common Antigen nanobodyAnti-L-Ca nanobodyAnti-Lymphocyte Antigen 5 nanobodyAnti-Ly-5 nanobodyAnti-T200 nanobodyAnti-Cd Antigen Cd45 nanobodyAnti-Ptprc nanobodyAnti-Ly-5 nanobody |
Information sourced from Uniprot.org
