Anti-CD42b antibody (15-531 aa) [SRM5367] (STJ11107277)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal CD42b (15-531 aa) antibody for use in IHC-P and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SRM5367 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | IHC-P:1:200-1:800ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GP1BA |
| Gene ID | 2811 |
| Uniprot ID | GP1BA_HUMAN |
| Immunogen Region | 15-531 aa |
| Immunogen Sequence | HPHPICEVSKVASHLEVNCD KRNLTALPPDLPKDTTILHL SENLLYTFSLATLMPYTRLT QLNLDRCELTKLQVDGTLPV LGTLDLSHNQLQSLPLLGQT LPALTVLDVSFNRLTSLPLG ALRGLGELQELYLKGNELKT LPPGLLTPTPKLEKLSLANN NLTELPAGLLNGLENLDTLL LQENSLYTIPKGFFGSHLLP FAFLHGNPWLCNCEILYFRR WLQDNAENVYVWKQGVDVK |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 15-531 of human CD42b (NP_000164.5). |
Additional Info
| Post Translational Modifications | Glycocalicin is the product of a proteolytic cleavage/shedding, catalyzed by ADAM17, which releases most of the extracellular domain. Binding sites for vWF and thrombin are in this part of the protein. |
| Function | GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium. |
| Protein Name | Platelet Glycoprotein Ib Alpha ChainGp-Ib AlphaGpib-AlphaGpibaGlycoprotein IbalphaAntigen Cd42b-AlphaCd Antigen Cd42b Cleaved Into - Glycocalicin |
| Database Links | Reactome: R-HSA-140837Reactome: R-HSA-430116Reactome: R-HSA-75892Reactome: R-HSA-76009Reactome: R-HSA-8936459Reactome: R-HSA-9673221Reactome: R-HSA-9845620Reactome: R-HSA-9846298 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Platelet Glycoprotein Ib Alpha Chain antibodyAnti-Gp-Ib Alpha antibodyAnti-Gpib-Alpha antibodyAnti-Gpiba antibodyAnti-Glycoprotein Ibalpha antibodyAnti-Antigen Cd42b-Alpha antibodyAnti-Cd Antigen Cd42b Cleaved Into - Glycocalicin antibodyAnti-GP1BA antibody |
Information sourced from Uniprot.org