Anti-CD300A antibody (18-180) (STJ112046)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CD300A (18-180) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:5000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CD300A |
| Gene ID | 11314 |
| Uniprot ID | CLM8_HUMAN |
| Immunogen Region | 18-180 |
| Immunogen Sequence | LSKCRTVAGPVGGSLSVQCP YEKEHRTLNKYWCRPPQIFL CDKIVETKGSAGKRNGRVSI RDSPANLSFTVTLENLTEED AGTYWCGVDTPWLRDFHDPV VEVEVSVFPASTSMTPASIT AAKTSTITTAFPPVSSTTLF AVGATHSASIQEETEEVVNS QLP |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 18-180 of human CD300A (NP_009192.2). |
Additional Info
| Tissue Specificity | Expressed not only by natural killer (NK) cells but also by T-cell subsets, B-cells, dendritic cells, mast cells, granulocytes and monocytes. |
| Post Translational Modifications | Phosphorylated on tyrosine. N-glycosylated. |
| Function | Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6. |
| Protein Name | Cmrf35-Like Molecule 8Clm-8Cd300 Antigen-Like Family Member ACmrf-35-H9Cmrf35-H9Cmrf35-HIrc1/Irc2Immunoglobulin Superfamily Member 12Igsf12Inhibitory Receptor Protein 60Irp60Nk Inhibitory ReceptorCd Antigen Cd300a |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Cmrf35-Like Molecule 8 antibodyAnti-Clm-8 antibodyAnti-Cd300 Antigen-Like Family Member A antibodyAnti-Cmrf-35-H9 antibodyAnti-Cmrf35-H9 antibodyAnti-Cmrf35-H antibodyAnti-Irc1/Irc2 antibodyAnti-Immunoglobulin Superfamily Member 12 antibodyAnti-Igsf12 antibodyAnti-Inhibitory Receptor Protein 60 antibodyAnti-Irp60 antibodyAnti-Nk Inhibitory Receptor antibodyAnti-Cd Antigen Cd300a antibodyAnti-CD300A antibodyAnti-CMRF35H antibodyAnti-IGSF12 antibodyAnti-HSPC083 antibody |
Information sourced from Uniprot.org