Anti-CD229 antibody [R02-1I0] (STJA0035148)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant protein of human CD229
General Information
| Short Description | Rabbit monoclonal anti-CD229 for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R02-1I0 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | LY9 |
| Gene ID | 4063 |
| Uniprot ID | LY9_HUMAN |
| Immunogen | Recombinant protein of human CD229 |
Additional Info
| Tissue Specificity | Increased surface expression on T-cells of systemic lupus erythematosus (SLE) patients. |
| Function | Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction. Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion.the costimulatory activity requires SH2D1A. Promotes recruitment of RORC to the IL-17 promoter. May be involved in the maintenance of peripheral cell tolerance by serving as a negative regulator of the immune response. May disable autoantibody responses and inhibit IFN-gamma secretion by CD4(+) T-cells. May negatively regulate the size of thymic innate CD8(+) T-cells and the development of invariant natural killer T (iNKT) cells. |
| Protein Name | T-Lymphocyte Surface Antigen Ly-9Cell Surface Molecule Ly-9Lymphocyte Antigen 9Slam Family Member 3Slamf3Signaling Lymphocytic Activation Molecule 3Cd Antigen Cd229 |
| Database Links | |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinCell Membrane |
| Alternative Antibody Names | Anti-T-Lymphocyte Surface Antigen Ly-9 antibodyAnti-Cell Surface Molecule Ly-9 antibodyAnti-Lymphocyte Antigen 9 antibodyAnti-Slam Family Member 3 antibodyAnti-Slamf3 antibodyAnti-Signaling Lymphocytic Activation Molecule 3 antibodyAnti-Cd Antigen Cd229 antibodyAnti-LY9 antibodyAnti-CDABP0070 antibody |
Information sourced from Uniprot.org