• Anti-CD163 Antibody (STJ500424): Rhesus macaque Mesenteric Lymph node- CD163. Primary Antibody: STJ500424, 1:100 dilution. Antigen retrieval reagents: Vector, high pH H3301 and low pH H3300 Secondary Antibody: goat anti-rabbit IgG (H+L) Alexa 488 A11008 (1:1000 dilution). 20X magnification.

Anti-CD163 antibody (887-905) (STJ500424)

SKU:
STJ500424-100

£441.50
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Host: Rabbit
Applications: ELISA/IF/IP/WB
Reactivity: Human/Monkey
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CD163 (887-905) is suitable for use in ELISA, Immunofluorescence, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.55-0.75 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
IP: 1:150
IF: 1:100
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Immunogen Region: 887-905
Immunogen: Synthetic peptide taken within amino acid region 887-905 on human CD163 protein.
Background Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance