• Human peripheral blood lymphocytes were stained with Anti-Human CD4 Monoclonal Antibody (FITC Conjugated) and Anti-CD161 antibody (STJA0000942)

Anti-CD161/KLRB1 antibody [HP-3G10] {PE/Cyanine7} (STJA0000942)

SKU:
STJA0000942

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Host: Mouse
Applications: FC
Reactivity: Human
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Killer cell lectin-like receptor subfamily B member 1 is suitable for use in Flow Cytometry research applications.
Clonality: Monoclonal
Clone ID: HP-3G10
Conjugation: PE/Cyanine7
Isotype: IgG1k
Formulation: PBS with 0.05% Proclin300, 1% BSA
Storage Instruction: Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.
Gene Symbol: KLRB1
Gene ID: 3820
Uniprot ID: KLRB1_HUMAN
Tissue Specificity Expressed in a subset of NK cells predominantly in intestinal epithelium and liver. Detected in peripheral blood T-cells and preferentially in adult T-cells with a memory antigenic phenotype.
Post Translational Modifications N-glycosylated. Contains sialic acid residues.
Function Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.
Protein Name Killer Cell Lectin-Like Receptor Subfamily B Member 1
C-Type Lectin Domain Family 5 Member B
Hnkr-P1a
Nkr-P1a
Natural Killer Cell Surface Protein P1a
Cd Antigen Cd161
Database Links Reactome: R-HSA-198933
Cellular Localisation Membrane
Single-Pass Type Ii Membrane Protein
Alternative Antibody Names Anti-Killer Cell Lectin-Like Receptor Subfamily B Member 1 antibody
Anti-C-Type Lectin Domain Family 5 Member B antibody
Anti-Hnkr-P1a antibody
Anti-Nkr-P1a antibody
Anti-Natural Killer Cell Surface Protein P1a antibody
Anti-Cd Antigen Cd161 antibody
Anti-KLRB1 antibody
Anti-CLEC5B antibody
Anti-NKRP1A antibody

Information sourced from Uniprot.org

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