| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | Mcam |
| Gene ID: | 84004 |
| Uniprot ID: | MUC18_MOUSE |
| Immunogen Region: | 24-563 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-563 of mouse CD146. (NP_075548.2). |
| Immunogen Sequence: | VPGEEKQPVPTPDLVEAEVG STALLKCGPSRASGNFSQVD WFLIHKERQILIFRVHQGKG QREPGEYEHRLSLQDSVATL ALSHVTPHDERMFLCKSKRP RLQDHYVELQVFKAPEEPTI QANVVGIHVDRQELREVATC VGRNGYPIPQVLWYKNSLPL QEEENRVHIQSSQIVESSGL YTLKSVLSARLVKEDKDAQF YCELSYRLPSGNHMKESKEV TVPVFYPAEKVWVEVEPVG |
| Tissue Specificity | Detected in melanoma cell lines. |
| Function | Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as a surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. |
| Protein Name | Cell Surface Glycoprotein Muc18 Gicerin Melanoma Cell Adhesion Molecule Melanoma-Associated Antigen Muc18 Cd Antigen Cd146 |
| Database Links | Reactome: R-MMU-8980692 Reactome: -MMU-9013026 Reactome: -MMU-9013106 Reactome: -MMU-9013149 Reactome: -MMU-9013404 Reactome: -MMU-9013405 Reactome: -MMU-9013408 Reactome: -MMU-9013423 Reactome: -MMU-9035034 |
| Cellular Localisation | Membrane Single-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Cell Surface Glycoprotein Muc18 antibody Anti-Gicerin antibody Anti-Melanoma Cell Adhesion Molecule antibody Anti-Melanoma-Associated Antigen Muc18 antibody Anti-Cd Antigen Cd146 antibody Anti-Mcam antibody Anti-Muc18 antibody |
Information sourced from Uniprot.org
