| Tissue Specificity | Brain, spinal cord, spleen, kidney, heart and liver. |
| Function | Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive. Probable cell adhesion protein. |
| Protein Name | Nectin-2Herpes Virus Entry Mediator BHerpesvirus Entry Mediator BHvebMurine Herpes Virus Entry Protein BMhvebNectin Cell Adhesion Molecule 2Poliovirus Receptor HomologPoliovirus Receptor-Related Protein 2Cd Antigen Cd112 |
| Database Links | Reactome: R-MMU-198933Reactome: -MMU-418990Reactome: -MMU-420597 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Nectin-2 antibodyAnti-Herpes Virus Entry Mediator B antibodyAnti-Herpesvirus Entry Mediator B antibodyAnti-Hveb antibodyAnti-Murine Herpes Virus Entry Protein B antibodyAnti-Mhveb antibodyAnti-Nectin Cell Adhesion Molecule 2 antibodyAnti-Poliovirus Receptor Homolog antibodyAnti-Poliovirus Receptor-Related Protein 2 antibodyAnti-Cd Antigen Cd112 antibodyAnti-Nectin2 antibodyAnti-Mph antibodyAnti-Pvr antibodyAnti-Pvrl2 antibodyAnti-Pvs antibody |
Information sourced from Uniprot.org
