Anti-CD105 antibody [MEM-226] (STJ16100186)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2a
ImmunogenRecombinant Vaccinia virus containing the human CD105 cDNA.
General Information
| Short Description | Mouse monoclonal anti-CD105 for use in FC, IP and WB in Rat and Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC/IP/WB |
| Host | Mouse |
| Reactivity | Rat/Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | MEM-226 |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Formulation | Phosphate buffered saline (PBS) solution with 15 mM sodium azide |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
| Immunogen | Recombinant Vaccinia virus containing the human CD105 cDNA. |
Additional Info
| Background | CD105 (endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels. |
Information sourced from Uniprot.org